| EMMA ID | common strain name(s) | targeted (or) expressed gene(s) (click on the name to search the allele or transgene description(s) in the Mouse Genome Database) | mutation (sub)type | (International) Strain Designation | click to order/register an interest |
| EM:01789 | Conductin (Axin2)-lacZ | axin2 | targeted/knock-in | Conductin (Axin2)-lacZ | order |
Genetic background : C57BL/6N
Phenotype description: no; minor: craniosynosthosis
Genetic description: Axin2 null mutation, knock-in of NLS-lacZ in frame following Axin2's ATG start codon. Antisense PGK-Neo cassette flanked by loxP-sites following lacZ. Only splice acceptor and donor of first coding exon (exon 2) left.
Original Producer: Jerchow Boris.
References:
- The role of Axin2 in calvarial morphogenesis and craniosynostosis.; Yu Hsiao-Man; Jerchow Boris, Sheu Tzong-Jen, Liu Bo, Costantini Frank, Puzas J, Birchmeier Walter, Hsu Wei; 2005; Development; 132; 1995-2005; 15790973
- Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.; Lustig Barbara; Jerchow Boris, Sachs Martin, Weiler Sigrid, Pietsch Torsten, Karsten Uwe, van de Wetering Marc, Clevers Hans, Schlag Peter, Birchmeier Walter, Behrens Jürgen; 2002; Mol Cell Biol; 22; 1184-93; 11809809
Availability:
- Frozen embryos. Delivered in 4 weeks. Price €1100.
- Rederivation of mice from frozen stock. Delivered in 4-6 months. Price €1700.
More detail on pricing and delivery times
Note:
Distribution of this strain is subject to a Material Transfer Agreement (MTA).
Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before frozen material or live mice can be shipped.